Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis
Identifieur interne : 000C72 ( Main/Exploration ); précédent : 000C71; suivant : 000C73Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis
Auteurs : Y. Fischer [Allemagne] ; S. Ritz [Allemagne] ; K. Weber [Allemagne] ; C. Sauter-Louis [Allemagne] ; K. Hartmann [Allemagne]Source :
- Journal of Veterinary Internal Medicine [ 0891-6640 ] ; 2011-11.
English descriptors
- Teeft :
- Alanine aminotransferase, Alkaline phosphatase, Automatic analyzer, Blood cells, Blood parameter, Brinogen levels, Cat, Control days, Cytokine, Decrease vasculitis, Feline, Feline coronavirus, General condition, Glucocorticoid, Glucocorticoid treatment, Hartmann, Infectious peritonitis, Intravascular coagulation, Leukemia virus, Median, Median survival, Median survival time, Molecular weight heparin, Neutrophil, Pentoxifylline, Peritonitis, Placebo, Placebo group, Present study, Product characteristics, Propentofylline, Randomized trial, Retrospective study, Room temperature, Sample diluent, Serum sample, Serum samples, Small animal biochemistry, Small animal medicine, Survival time, Time point, Total protein, Treatment initiation, Treatment option, Tumor necrosis factor, Vasculitis, White blood cells.
Abstract
Background: Currently there is no drug proven to effectively treat cats with feline infectious peritonitis (FIP). Hypothesis: Propentofylline (PPF) can decrease vasculitis, and therefore prolong survival time in cats with FIP, and increase their quality of life. Animals: Twenty‐three privately owned cats with FIP. Methods: Placebo‐controlled double‐blind trial. FIP was confirmed by histology or immunostaining of feline coronavirus (FCoV) antigen in effusion or tissue macrophages or both. The cats were randomly selected for treatment with either PPF or placebo. All cats received additional treatment with glucocorticoids, antibiotics, and low molecular weight heparin according to methods. Results: There was no statistically significant difference in the survival time of cats treated with PPF (8 days, 95% CI 5.4–10.6) versus placebo (7.5 days, 95% CI 4.4–9.6). The median survival time of all cats was 8 days (4–36 days). There was neither a difference in quality of life (day 7, P = .892), in the amount of effusion (day 7, P = .710), the tumor necrosis factor‐alpha (TNF‐α) concentration (day 7, P = .355), nor in any other variable investigated in this study, including a complete blood count, and a small animal biochemistry profile. Conclusions and Clinical Importance: This study did not detect an effect of PPF on the survival time, the quality of life, or any clinical or laboratory parameter in cats with FIP. Therefore, PPF does not appear to be an effective treatment option in cats with a late stage of the disease FIP.
Url:
DOI: 10.1111/j.1939-1676.2011.00806.x
Affiliations:
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Hypothesis: Propentofylline (PPF) can decrease vasculitis, and therefore prolong survival time in cats with FIP, and increase their quality of life. Animals: Twenty‐three privately owned cats with FIP. Methods: Placebo‐controlled double‐blind trial. FIP was confirmed by histology or immunostaining of feline coronavirus (FCoV) antigen in effusion or tissue macrophages or both. The cats were randomly selected for treatment with either PPF or placebo. All cats received additional treatment with glucocorticoids, antibiotics, and low molecular weight heparin according to methods. Results: There was no statistically significant difference in the survival time of cats treated with PPF (8 days, 95% CI 5.4–10.6) versus placebo (7.5 days, 95% CI 4.4–9.6). The median survival time of all cats was 8 days (4–36 days). There was neither a difference in quality of life (day 7, P = .892), in the amount of effusion (day 7, P = .710), the tumor necrosis factor‐alpha (TNF‐α) concentration (day 7, P = .355), nor in any other variable investigated in this study, including a complete blood count, and a small animal biochemistry profile. Conclusions and Clinical Importance: This study did not detect an effect of PPF on the survival time, the quality of life, or any clinical or laboratory parameter in cats with FIP. Therefore, PPF does not appear to be an effective treatment option in cats with a late stage of the disease FIP.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Fischer, Y" sort="Fischer, Y" uniqKey="Fischer Y" first="Y." last="Fischer">Y. Fischer</name></region><name sortKey="Hartmann, K" sort="Hartmann, K" uniqKey="Hartmann K" first="K." last="Hartmann">K. Hartmann</name><name sortKey="Hartmann, K" sort="Hartmann, K" uniqKey="Hartmann K" first="K." last="Hartmann">K. Hartmann</name><name sortKey="Ritz, S" sort="Ritz, S" uniqKey="Ritz S" first="S." last="Ritz">S. Ritz</name><name sortKey="Sauter Ouis, C" sort="Sauter Ouis, C" uniqKey="Sauter Ouis C" first="C." last="Sauter-Louis">C. Sauter-Louis</name><name sortKey="Weber, K" sort="Weber, K" uniqKey="Weber K" first="K." last="Weber">K. Weber</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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